ＮＫ细胞的调制方法;METHOD FOR PREPARING NK CELLS

摘要

不用动物的血清或饲养细胞，开发可由造血前驱细胞以高纯度调制具有高细胞伤害活性的NK细胞的技术。;NK细胞的扩增方法，系包含：以使用含有IL-15、SCF、IL-7及Flt3L的培养基的单一培养条件将造血前驱细胞扩增的步骤，及以使用含有IL-2的培养基的培养条件，使在前述扩增的步骤所得的细胞分化诱导为NK细胞的步骤。以及，包含藉由本发明的NK细胞扩增方法所调制的NK细胞的医药品组成物。本发明的医药品组成物是可用于感染症及/或癌的治疗。;The amplification method of NK cells comprises a step of amplifying hemopoietic progenitor cells with a single cultural condition using a medium comprising IL-15, SCF, IL-7 and Flt3L; a step of differentiating induction the cells obtained from the previous amplification step into NK cells with a cultural condition using a medium comprising IL-2. And, a pharmaceutical composition comprising the NK cells prepared by the amplification method of NK cells of the present invention is provided. The pharmaceutical composition of the present invention is useful in the treatment of infection and/or cancer.