发明名称 DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES
摘要 A compound having the structure (I) or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, deuterium, -OH, -OC1-6alkyl, or halogen; R8 is hydrogen, deuterium, or C1-6alkyl; R11 and R12 are independently hydrogen, -C1-6alkyl, -OH, -OC1-6alkyl, or halogen; R13 and R14 are independently -C1-6alkyl, -(CH2)1-2OH, or -OC1-6alkyl, or, together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or mono-, di- or tri-substituted with halogen or -C1-6alkyl; R15 is -C(O)OH, -C(O)OCH2CH2N+CH3)3 wherein n is 0, 1 or 2, -C(O)NHCH(R17)OR16, or -C(O)NHCH(R17)C(O)NHCH(R18)C(O)OR16; R16 is hydrogen, C1-6alkyl, or (CH2)1-2N+R19R20R21; R1, R2, R4, R5, R6, R7, R9, R10, R17, R18, R19, R20, and R21 are independently hydrogen or -C1-6alkyl; and stereoisomers thereof, and pharmaceutically acceptable salts thereof, and pharmaceutically acceptable salts of stereoisomers thereof.
申请公布号 EP2571351(A4) 申请公布日期 2015.04.01
申请号 EP20110784021 申请日期 2011.05.16
申请人 MERCK SHARP & DOHME CORP. 发明人 ALI, AMJAD;YAN, LIN;HUO, PEI;NARGUND, RAVI
分类号 A01N33/26;A61K31/13;A61K31/15;C07B59/00;C07C291/02 主分类号 A01N33/26
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