| 摘要 |
The present invention provides a novel P2X 3 and/or P2X 2 / 3 receptor antago nist. A compound represented by the formula (I):
wherein R a , R b and R c are,
(a) R a and R b are taken together =Z; and R c is a group represented by R 1c ; or
(b) R b and R c are taken together to form a bond; and R a is a group represented by -Y-R 1a ;
R 1a and R 1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R 2 and R 3 are each independently substituted or unsubstituted aryl, etc.;
R 4a and R 4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is -N(R 5 )-, etc.;
R 5 is hydrogen, substituted or unsubstituted lower alkyl, etc.;
-Y- is -O-, etc.;
=Z is =O, etc.; and
n is an integer of 0 to 4. |
