| 摘要 |
<p>The invention comprises 5-nitro-2-furaldehyde semicarbazones of the formula <FORM:1020494/C2/1> wherein R1 is a 2-hydroxy-1-cycloalkyl radica1 with 5 to 7 ring members and 5 to 10 carbon atoms, and R2 is a hydrogen atom or a C1- 3 alky or phenyl radical. The compounds are prepared by (a) reacting, in a solvent, 5-nitro-2-furaldehyde, or a functional derivative thereof, with a semicarbazide of the formula <FORM:1020494/C2/2> or a reactive derivative or acid addition salt thereof; or (b) reacting a semicarbazone of the formula <FORM:1020494/C2/3> with a nitrating agent in the presence of a waterbinding agent; or (c) reacting, in an inert solvent, a hydrazone of the formula <FORM:1020494/C2/4> with cyanic acid or with an isocyanate of the formula O=C=N-R21 wherein R21 represent a C1- 3 alkyl or phenyl radical. The preparation of 2 - hydroxy cyclopentylhydrazine, 2 - (21 - hydroxy - cyclopentyl) - 4-phenyl - semi - carbazide, 5 - nitro - 2 - furaldehyde - N1 - (211 - hydroxycyclopentyl) - hydrazone, acetone - N1 - (211 - hydroxycyclopentyl) - hydrazone and acetaldehyde - 21 - (211 - hydroxycyclopentyl) - 41 - phenyl - semicarbazone is described. Pharmaceutical compositions having anti-bacterial, antifungal and coccidiostatic activity comprise a compound of the invention together with a conventional solid carrier or liquid diluent.</p> |
