| 主权项 |
1. A compound according Formula Icor a pharmaceutically acceptable salt thereof, wherein
E1 and E2 are independently C or N; ring B is phenyl or heteroaryl, R3 is CN, halo or C1-4alkyl, optionally substituted with 1-5 halo atoms, and each R6 is independently selected from the group consisting of: CN, halo, R5, —O—R5, —N(R)—R5, —N(R)C(O)—R5, —N(R)S(O)2—R5, —N(R)—C(O)—O—R5, —C(O)—N(R)—R5, —C(O)—O—R5, —C(O)—R5, —C(O)—C(R4)2—R5, —C(O)—C(R4)2—S(O)2—R5, —C(R4)2—N(R)—R5, —SO2—N(R)—R5, —Si(CH3)2(R5), —C(R4)2—R5 and —SO2—R5; each R is independently selected from the group consisting of: H and C1-4alkyl; each R4 is independently selected from the group consisting of: H, OH and C1-4alkyl; each R5 is independently selected from the group consisting of: H, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C3-6cycloalkyl, phenyl, benzyl, heterocycle and heteroaryl, wherein each member of the group excluding hydrogen is optionally substituted with 1 to 3 substituents independently selected from: halogen, cyano, hydroxy and methyl; Z is selected from H, halo, hydroxy, methyl, methoxy or CN; R1 is selected from the group consisting of:
(1) C2-8alkyl,(2) C2-8alkenyl,(3) C2-8alkynyl,(4) C3-6cycloalkyl-(CH2)p—,(5) aryl-(CH2)p—,(6) heteroaryl-(CH2)p—, and(7) heterocycle-(CH2)p—, wherein p is 0, 1, 2, 3 or 4, and groups (1) to (7) above are optionally substituted with 1 to 4 R2 groups; and each R2 is independently selected from the group consisting of: halo, OH, —CN, C1-4alkyl, C1-4alkoxy, CF3, —OCF3, —C(O)—O—C1-4alkyl, —N(R)2, pyrimidinyl and —CN. |
