Topical pharmaceutical compositions containing nanodroplets for the treatment psoriasis

摘要

The present invention relates to stable topical pharmaceutical compositions for the treatment of psoriasis. Disclosed are in particular nonoemulsions comprising nano size droplets of one or more anti-psoriasis agents, e.g. clobetasol and/or salicylic acid. These compositions exhibit greater permeability, and improved bioavailability. The invention also relates to processes for the preparation of such compositions.

主权项

1. A stable topical pharmaceutical composition comprising:
(a) 0.01-0.5% clobetasol or a salt or ester thereof; (b) 4-8% salicylic acid (c) 1-5% lactic acid (d) 1-5% polyoxyethylene (20) sorbitan monooleate (e) 3-7% of alcohol (f) 3-7% of lipids (g) 7-12% of oils (h) 0.05-0.5% of butylated hydroxytoluene (i) 0.5-3% a carbomer (j) one or more pH adjusting agents, and (k) water; wherein the composition comprises a particle size of about 250 nm and a pH of about 5.87.