Multicomponent degradable cationic polymers

摘要

Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.

主权项

1. A compound of Formula (I):wherein:each m is independently an integer selected from the group consisting of 3, 4, 5, 6, and 8;n is an integer from 1 to 10,000;
R′ is a side chain comprising a functional group selected from the group consisting of —OH, —NH2 and —SH; and R″ is selected from the group consisting of:and
pharmaceutically acceptable salts thereof.