Liposomes useful for drug delivery

摘要

The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention.

主权项

1. A liposomal composition comprising liposomes in an aqueous medium, the liposomes having an interior aqueous space separated from the aqueous medium by a membrane comprising 1,2-distearoyl-SN-phosphatidylcholine, cholesterol and N-(omega-methoxy-poly(ethylene glycol)-oxycarbonyl)-1,2-distearoylphosphatidyl ethanolamine, and entrapped inside the liposomes are either: 1) irinotecan and sucrose octasulfate, or 2) irinotecan, sucrose octasulfate and a substituted ammonium compound; wherein, the irinotecan entrapped inside the liposomes is at a concentration that exceeds the concentration of the irinotecan in the aqueous medium.