| 发明名称 |
RANKL antibody-PTH/PTHrP chimeric molecules |
| 摘要 |
Chimeric molecules comprising receptor activator of NF-κB ligand (RANKL) antibodies and parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) peptides are described. Compositions and methods for the treatment of bone diseases are also described. |
| 申请公布号 |
US8992925(B2) |
申请公布日期 |
2015.03.31 |
| 申请号 |
US200611599629 |
申请日期 |
2006.11.13 |
| 申请人 |
Amgen Inc. |
发明人 |
Kostenuik Paul;Shen Wenyan;Boone Thomas C. |
| 分类号 |
A61K39/395;C07K16/24;A01K67/027;C07K14/635;C07K14/705;C07K16/28;A61K39/00 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
Ausenhus Scott L. |
| 主权项 |
1. A receptor activator of NF-κB ligand (RANKL) antibody-parathyroid hormone/parathyroid hormone related protein (PTH/PTHrP) chimeric molecule, comprising:
(a) an antibody that binds to RANKL; and (b) a PTH/PTHrP peptide comprising a PTH/PTHrP modulating domain;wherein the PTH/PTHrP peptide is operably linked to the antibody. |
| 地址 |
Thousand Oaks CA US |
