发明名称 |
Antagonists of IL-17A, IL-17F, and IL-23P19 |
摘要 |
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A, IL-17F, and IL-23. Antagonists include antibodies and antibody fragments that bind IL-23 and that bind IL-17A or IL-17F, such as antibodies that are cross-reactive for IL-17A and Il-17F. Antagonists that include an antibody or antibody fragment that binds IL-23 and an antibody or antibody fragment that binds IL-17A or IL-17F on one molecule are also disclosed. Antibodies and antibody fragments that bind IL-23 and IL-17F but that do not bind IL-17A are also disclosed. IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease. |
申请公布号 |
US8992922(B2) |
申请公布日期 |
2015.03.31 |
申请号 |
US201313929226 |
申请日期 |
2013.06.27 |
申请人 |
ZymoGenetics, Inc. |
发明人 |
Lewis Katherine E.;Presnell Scott R.;Levin Steven D.;Mabry Robert;Jaspers Stephen R.;Huber Monica J. |
分类号 |
A61K39/00;A61K39/395;C07K16/24 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
Walsh Brian J. |
主权项 |
1. A bispecific antibody comprising a cross-reactive IL-17A and IL-17F binding entity and an IL-23p19 binding entity, wherein the cross-reactive IL-17A and IL-17F binding entity is a humanized antibody or antigen-binding fragment thereof derived from the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-7988, and the IL-23p19 binding entity comprises an antibody or antigen-binding fragment thereof which specifically binds to the p19 subunit of IL-23. |
地址 |
Seattle WA US |