Forming porous scaffold from cellulose derivatives

摘要

Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.

主权项

1. A method of forming a scaffold, comprising:
forming a bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase, said polymer phase comprising hydroxypropylcellulose substituted by a substituent, said substituent comprising a self-crosslinkable group; crosslinking said substituted hydroxypropylcellulose through said self-crosslinkable group in said bicontinuous emulsion to form a polymer defining interconnected pores, wherein said crosslinking comprises irradiating said emulsion with γ-ray.