Peptides and methods using same for diagnosis and treatment of amyloid-associated disease

摘要

Peptides having at least 2 amino acids and no more than 15 amino acids are provided. The peptides comprise amino acid sequence X-Y or Y-X, wherein X is an aromatic amino acid and Y is any amino acid other than glycine. Also provided are pharmaceutical compositions and kits including such peptides as well as methods using same for diagnosing and treating amyloid associated diseases.

主权项

1. A method of treating an amyloid-associated disease in an individual in need thereof, the method comprising systemically administering to the individual a therapeutically effective amount of a synthetic dipeptide having the general Formula: wherein: C* is a chiral carbon having a D configuration;
R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carboxy, C-thiocarb; R3 is selected from the group consisting of hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, halo and amine; and R4 is alkyl, thereby treating the amyloid-associated disease in the individual.