Prion protein based hemin binders and methods of use

摘要

Methods of using portions of the N-terminal domain of prion protein for binding hemin are disclosed. In a particular embodiment, a method comprises administering at least one isolated amino acid sequence comprising a peptide from the octarepeat region of PrPC to a solution containing hemin, wherein the isolated amino acid sequence is effective for forming one or more chemical bonds with hemin.

主权项

1. A method of treating a condition characterized by cellularly toxic hemin levels, the method comprising administering a composition comprising an isolated amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 3, 4, 5, 6, and combinations thereof to a subject identified as having a condition characterized by cellularly toxic hemin levels.