Method of preventing and treating inflammatory diseases and disorders with abscisic acid

摘要

The present invention relates to the use of a therapeutically effective amount of abscisic acid (ABA) or its analogs to treat or prevent inflammation induced by exposure to lipopolysaccharide (LPS) or respiratory inflammation. The invention also relates to methods and composition for enhancing vaccine efficacy using ABA.

主权项

1. A method of treating respiratory inflammation in a mammal, the method comprising administering to the mammal a composition containing one or more compounds selected from: abscisic acid (ABA) in its free acid form, esters thereof, pharmaceutically suitable salts thereof, metabolites thereof, structurally related compounds thereof, and analogs thereof, in amounts that are sufficient to decrease mucosal and submucosal inflammatory cell infiltration, perivascular cuffing, terminal airway infiltration, or epithelial necrosis in the lung, wherein the inflammation is caused by an infection of a respiratory pathogen selected from the group consisting of influenza virus rhinovirus respiratory syncytial virus, parainfluenza, Staphylococcus aureus, Streptococcus pneumoniae, Francisella tularensis, Mycobacterium tuberculosis and Bacillus anthracis.