| 主权项 |
1. A compound of formula I or salt thereof where Q is thiazole optionally substituted with R1; Z is a single bond; X1 and X2 together form ═O; R1 is
(1) hydrogen or R6,
where R6 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo, or heterocycloalkyl, each of which is unsubstituted or substituted with Z1, Z2 and one or more groups Z3; q is 1 or 2; R2 is hydrogen, R6, —Z4—R6 or —Z13—NR7R8; R3 is —Z13—NR7R8 where Z13 is —C(O)—; R4 and R5 (1) are each independently hydrogen or R6;(2) —Z4—N(R9)—Z5—NR10R11;(3) —N(R9)Z4R6; or R7 is alkyl; R8, R9, R10, R11 and R12 (1) are each independently hydrogen or R6; R13 is
(1) cyano;(2) nitro;(3) —NH2;(4) —NHOalkyl;(5) —OH;(6) —NHOaryl;(7) —NHCOOalkyl;(8) —NHCOOaryl;(9) —NHSO2alkyl;(10) —NHSO2aryl;(11) aryl;(12) heteroaryl;(13) —Oalkyl; or(14) —Oaryl; R14 is
(1) —NO2;(2) —COOalkyl; or(3) —COOaryl; Z1, Z2 and Z3 are each independently
(1) hydrogen or Z6, where Z6 is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkylaryl, heterocyclo, or heterocycloalkyl; (ii) a group (i) which is itself substituted by one or more of the same or different groups (i); or (iii) a group (i) or (ii) which is substituted by one or more of the following groups (2) to (16) of the definition of Z1, Z2 and Z3;(2) —OH or —OZ6;(3) —SH or —SZ6;(4) —C(O)qH, —C(O)qZ6, or —O—C(O)qZ6;(5) —SO3H, —S(O)qZ6; or S(O)qN(Z9)Z6;(6) halo;(7) cyano;(8) nitro;(9) —Z4—NZ7Z8;(10) —Z4—N(Z9)—Z5—NZ7Z8;(11) —Z4—N(Z10)—Z5—Z6;(12) —Z4—N(Z10)—Z5—H;(13) oxo; or(14) —O—C(O)—Z6; Z4 and Z5 are each independently
(1) a single bond;(2) —Z11—S(O)q—Z12—;(3) —Z11—C(O)—Z12—;(4) —Z11—C(S)—Z12—;(5) —Z11—O—Z12—;(6) —Z11—S—Z12—;(7) —Z11—O—C(O)—Z12—; or(8) —Z11—C(O)—O—Z12—; Z7, Z8, Z9 and Z10 (1) are each independently hydrogen or Z6; Z11 and Z12 are each independently
(1) a single bond;(2) alkylene;(3) alkenylene; or(4) alkynylene; and Z13 is
(1) a single bond;(2) —Z11—S(O)qZ12—;(3) —Z11—C(O)—Z12—;(4) —Z11—C(S)—Z12—;(5) —Z11—O—Z12—;(6) —Z11—S—Z12—;(7) —Z11—O—C(O)—Z12—;(8) —Z11—C(O)—O—Z12—;(9) —C(NR13)—;(10) —C(CHR14)—; or(11) —C(C(R14)2)— provided said compound is other than a compound of formula (ix) whereR2i is hydrogen or alkyl;R3i is —C(O)—NH-(alk); andR58 and R59 are independently hydrogen, alkyl or halogen. |
