| 主权项 |
1. a compound of the formula Iin which
R1 denotes H, A, CH2CN, CH2CONH2, CH2CONHA′, CH2CONA′2, CH2COOH, CH2COOA′ or CH2COHet1, R2 denotes (CH2)nAr, COAr, (CH2)nHet, Cyc, Alk or A, R3 denotes CH3 or (CH2)nNHCOOA′, R4 denotes phenyl, Alk denotes unbranched or branched alkenyl having 2-6 C atoms, A denotes unbranched or branched alkyl having 1-8 C atoms, in which one or two non-adjacent CH2 and/or CH groups may be replaced by O, N and/or S atoms and/or 1-7 H atoms may be replaced by F and/or Cl, A′ denotes unbranched or branched alkyl having 1-4 C atoms, Cyc denotes cycloalkyl having 3-7 C atoms, Ar denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, (CH2)2CN, (CH2)2COOH, (CH2)2COOA, (CH2)2OH, (CH2)2OA, COHet1, O(CH2)2R4, NO2, CONHHet1, NHCOCyc, CONH(CH2)2CONH2, CONH(CH2)2CONHA′, CONH(CH2)2CONA′2, CONH2, CONHA′, CONA′2, NHCOAlk, CONHCH(R4)CONH2, CONH(CH2)nCONHHet1, CONH(CH2)nCOHet1 and/or CONH(CH2)nCyc, Het denotes a mono- or bicyclic aromatic heterocycle having 1 to 4 N, and/or O and/or S atoms which is unsubstituted or mono- or disubstituted by Hal and/or A, Het1 denotes a monocyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, and/or O and/or S atoms which is unsubstituted or mono- or disubstituted by A, Hal denotes F, Cl, Br or I, n denotes 0, 1 or 2, or pharmaceutically acceptable salts, tautomers and stereoisomers thereof. |
