Coated devices and method of making coated devices that reduce smooth muscle cell proliferation and platelet activity

摘要

The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.

主权项

1. A drug eluting intravascular stent comprising:
(a) a generally cylindrical stent body; (b) an adherent layer on the stent comprising a composite of polymer and a first active agent selected from a group consisting of resveratrol, pharmaceutically acceptable salts thereof, and pharmaceutically acceptable derivatives thereof, and a second active agent selected from a group consisting of quercetin, pharmaceutically acceptable salts thereof, and pharmaceutically acceptable derivatives thereof, wherein said first and second active agents are dispersed within the polymer, wherein the concentration of the first active agent based on a surface area of the stent ranges from about 1 to about 5 μg/mm2, and the concentration of the second active agent based on the surface area of the stent ranges from about 1 to about 5 μg/mm2, and wherein the composite includes a plurality of layers.