Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars

摘要

Process for the preparation of trivalent iron complexes with mono-, di- and polysaccharide sugars, consisting of the activation of the sugar by oxidation with nascent bromine generated in situ by reaction between an alkaline or alkaline earth bromine and an alkaline hypochlorite, the complexation of the activated sugar in solution with a ferric salt dissolved in an aqueous solution, the purification of the resulting solution through ultrafiltration and finally the stabilization of the trivalent iron-sugar complex by heating at a temperature between 60° C. and 100° C. for a period between 1 and 4 hours at a pH between 9.0 and 11.0.

主权项

1. A process for the preparation of an activated sugar Fe(III)-complex, wherein said sugar is selected from the group consisting of mono- or disaccharide sugars, said process comprising:
(a) providing a solution comprising said sugar to be activated and bromine, characterized in that said bromine is produced in situ in the presence of said sugar to be activated at a pH in the range from 5 to 12 through the addition of stoichiometric quantities with respect to the aldehyde end groups of said sugar of a hypochlorite of an alkaline or earth alkaline metal to a solution comprising said sugar to be activated and a bromide of an alkaline or earth alkaline metal, wherein the addition of hypochlorite is carried out instant-by-instant in a way such that all the added hypochlorite only serves for the bromide oxidation and an excess of hypochlorite in solution is never present, thereby producing an activated sugar solution wherein the end aldehyde group is oxidized, (b) adding a water soluble ferric salt to the activated sugar solution, such that the resulting solution contains the activated sugar and the iron (III) salt in an iron to sugar weight ratio between 1:0.5 and 1:5, whereafter the pH of the solution is controlled at a value between from 2.3 to 2.7 by adding a sodium hydrogencarbonate or a sodium carbonate solution in a time between 1 and 6 hours; (c) bringing the pH of the solution as per step (b) subsequently to a value between 8 and 12, to give a solution containing the Fe (III)-activated sugar complex, and (d) purifying the Fe (III)-activated sugar complex.