Devices with multiple surface functionality

摘要

Phosphorus-based coatings having a plurality of phosphate moieties, a plurality of phosphonate moieties, or both, covalently bonded to an oxide surface of an implantable substrate exhibiting one or more of the following characteristics: (a) the surface phosphorus-containing group density of the coated regions of the substrate is at least about 0.1 nmol/cm2; (b) the phosphorus-based coating has a thickness of less than about 10 nm; or (c) the surface phosphorus-containing group density of the coated regions of the substrate is equal to or greater than the surface hydroxyl group density of the oxide surface of the substrate. Implantable devices embodying the coated substrates are also disclosed.

主权项

1. A device comprising:
(i) a substrate comprising an oxide surface; (ii) a coating comprising a plurality of organophosphonate moieties covalently bonded to the oxide surface of the substrate; and (iii) an anti-infective compound directly attached to said organophosphonate moieties via a reactive functional group on the organophosphonate organo moieties, which reactive functional group is selected from the group consisting of hydroxyl, carboxylic acid, carboxylic ester, amino, thiol, phosphonic acid, phosphoric acid, sulfonic acid, and combinations of two or more thereof, and which reacts directly with said anti-infective compound to form a covalent bond.