| 发明名称 | Immobilised biological entities | ||
| 摘要 | There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole. | ||
| 申请公布号 | US8992963(B2) | 申请公布日期 | 2015.03.31 |
| 申请号 | US200912559660 | 申请日期 | 2009.09.15 |
| 申请人 | Carmeda AB | 发明人 | Oscarson Stefan;Lahmann Martina;Leontein Karin;Vestberg Robert |
| 分类号 | A61K9/00;A61K31/727;A61P7/02;A61K31/715;A61L27/34;A61L27/54;A61L33/00 | 主分类号 | A61K9/00 |
| 代理机构 | Klauber & Jackson LLC | 代理人 | Klauber & Jackson LLC |
| 主权项 | 1. A medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising a heparin moiety which is covalently end point attached through position C1 of its reducing terminal to said surface through a link comprising a 1,2,3-triazole wherein the device has an antithrombin III binding activity of at least 2 picomoles antithrombin III per square centimeter (pmol/cm2) of surface. | ||
| 地址 | Upplands Vasby SE | ||