| 主权项 |
1. A compound or a pharmaceutically acceptable salt thereof, said compound being represented by Formula V: wherein: G is H or halo; X is selected from the group consisting of H, F, OR2 and alkyl; Y is selected from the group consisting of H, F, OR2 and alkyl; with the proviso that when X═Y═OR2, R2 cannot be H; the “A” ring moiety: refers to a 5-7 membered heterocyclyl ring or a 5-7 membered heterocyclenyl ring and the N atom signifies a nitrogen atom on the ring moiety A, said heterocyclyl and heterocyclenyl ring containing 1-2 heteroatoms independently selected from O, S and N including the N atom shown in the ring moiety A, wherein said N atom shown in ring moiety A is the point of attachment of ring moiety A to the moiety: in Formula V, further wherein each of said heterocyclyl and heterocyclenyl ring independently is:
(i) either unsubstituted, or(ii) optionally independently substituted with one or more moieties which can be the same or different and are independently selected from halo, CN, hydroxy, alkyl, alkenyl, haloalkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkoxy, alkoxyalkyl, hydroxyalkyl, aryloxy, aryloxyalkyl, heteroaryl, heteroarylalkyl, —NH2, —NH(alkyl), —N(alkyl)2, —NH(aryl), —N(aryl)2, —N(alkyl)(aryl), —N(alkyl)(heterocyclyl), —N(aryl)(heterocyclyl), —NH(heteroaryl), —N(heteroaryl)2, —N(alkyl)(heteroaryl), —N(heteroaryl)(heterocyclyl), —NH(heterocyclyl), —N(heterocyclyl)2, heterocyclyl and heterocyclylalkyl, or(iii) optionally independently fused with an aryl, heteroaryl or heterocyclyl ring, wherein each of said heterocyclyl and heterocyclenyl ring of A and each of said fused aryl, heteroaryl and heterocyclyl ring can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different and are independently selected from halo, CN, hydroxy, alkyl, alkenyl, haloalkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkoxy, alkoxyalkyl, hydroxyalkyl, aryloxy, aryloxyalkyl, heteroaryl, heteroarylalkyl, —NH2, —NH(alkyl), —N(alkyl)2, —NH(aryl), —N(aryl)2, —N(alkyl)(aryl), —N(alkyl)(heterocyclyl), —N(aryl)(heterocyclyl), —NH(heteroaryl), —N(heteroaryl)2, —N(alkyl)(heteroaryl), —N(heteroaryl)(heterocyclyl), NH(heterocyclyl), —N(heterocyclyl)2, heterocyclyl and heterocyclylalkyl, or(iv) both (a) optionally independently substituted with one or more moieties which can be the same or different and are independently selected from halo, CN, hydroxy, alkyl, alkenyl, haloalkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkoxy, alkoxyalkyl, hydroxyalkyl, aryloxy, aryloxyalkyl, heteroaryl, heteroarylalkyl, —NH2, —NH(alkyl), —N(alkyl)2, —NH(aryl), —N(aryl)2, —N(alkyl)(aryl), —N(alkyl)(heterocyclyl), —N(aryl)(heterocyclyl), —NH(heteroaryl), —N(heteroaryl)2, —N(alkyl)(heteroaryl), —N(heteroaryl)(heterocyclyl), NH(heterocyclyl), —N(heterocyclyl)2, heterocyclyl and heterocyclylalkyl, and (b) optionally independently fused with an aryl, heteroaryl or heterocyclyl ring, wherein each of said heterocyclyl and heterocyclenyl ring of A and each of said fused aryl, heteroaryl and heterocyclyl ring can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different and are independently selected from halo, CN, hydroxy, alkyl, alkenyl, haloalkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkoxy, alkoxyalkyl, hydroxyalkyl, aryloxy, aryloxyalkyl, heteroaryl, heteroarylalkyl, —NH2, —NH(alkyl), —N(alkyl)2, —NH(aryl), —N(aryl)2, —N(alkyl)(aryl), —N(alkyl)(heterocyclyl), —N(aryl)(heterocyclyl), —NH(heteroaryl), —N(heteroaryl)2, —N(alkyl)(heteroaryl), —N(heteroaryl)(heterocyclyl), —NH(heterocyclyl), —N(heterocyclyl)2, heterocyclyl and heterocyclylalkyl, provided that when the “A” ring moiety: is pyridine, the “A” ring moiety: is fused with an aryl, heteroaryl or heterocyclyl ring, wherein each of said heterocyclyl and heterocyclenyl ring of A and each of said fused aryl, heteroaryl and heterocyclyl ring can be unsubstituted or optionally independently substituted with one or more moieties which can be the same or different and are independently selected from halo, CN, hydroxy, alkyl, alkenyl, haloalkyl, cycloalkyl, aryl, arylalkyl, alkylaryl, alkoxy, alkoxyalkyl, hydroxyalkyl, aryloxy, aryloxyalkyl, heteroaryl, heteroarylalkyl, —NH2, —NH(alkyl), —N(alkyl)2, —NH (aryl), —N(aryl)2, —N(alkyl)(aryl), —N(alkyl)(heterocyclyl), —N(aryl)(heterocyclyl), —NH(heteroaryl), —N(heteroaryl)2, —N(alkyl)(heteroaryl), —N(heteroaryl)(heterocyclyl), NH(heterocycly), —N(heterocycly)2, heterocyclyl and heterocyclylalkyl; R2 is selected from the group consisting of H, -alkyl, -aryl and -heteroaryl, wherein each of said alkyl, aryl and heteroaryl can be unsubstituted or optionally independently substituted with one or more groups which can be the same or different and are independently selected from the group consisting of halo, cyano, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, heteroaryl, heterocyclyl, heterocyclenyl, cycloalkyl, cycloalkenyl, —OH, alkoxy, aryloxy, heteroaryloxy, —NHR4, —NR4R5, —C(O)H, —C(O)alkyl, —C(O)aryl, —C(O)heteroaryl, —C(O)NHR4, —C(O)NR4R5; or
R4 and R5 in —NR4R5 can be connected to the N of said —NR4R5 to form a 5-8 membered heterocyclyl ring containing 1-3 heteroatoms including the N of said —NR4R5, and independently R4 and R5 in said —C(O)NR4R5 can be connected to the N of said —C(O)NR4R5 to form a 5-8 membered heterocyclyl ring containing 1-3 heteroatoms including the N of said —C(O)NR4R5; R4 is selected from the group consisting of H, -alkyl, -aryl and -heteroaryl, wherein each of said alkyl, aryl and heteroaryl can be unsubstituted or optionally independently substituted with one or more groups which can be the same or different and are independently selected from the group consisting of halo, cyano, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, heteroaryl, heterocyclyl, heterocyclenyl, cycloalkyl, cycloalkenyl, —OH, —OR6, —NHR6, —N(alkyl)R6, —N(aryl)R6, —N(heteroaryl)R6, —C(O)H, —C(O)R6, —C(O)NHR6, —C(O)N(alkyl)R6, —C(O)N(aryl)R6, and —C(O)N(heteroaryl)R6; R5 is selected from the group consisting of H, -alkyl, -aryl and -heteroaryl, wherein each of said alkyl, aryl and heteroaryl can be unsubstituted or optionally independently substituted with one or more groups which can be the same or different and are independently selected from the group consisting of halo, cyano, alkyl, alkenyl, alkynyl, hydroxyl, alkoxy, aryloxy, alkylthio, arylthio, aryl, heteroaryl, heterocyclyl, heterocyclenyl, cycloalkyl, cycloalkenyl, —OH, —OR7, —NHR7, —N(alkyl)R7, —N(aryl)R7, —N(heteroaryl)R7, —C(O)H, —C(O)R7, —C(O)NHR7, —C(O)N(alkyl)R7, —C(O)N(aryl)R7 and —C(O)N(heteroaryl)R7; R6 is selected from the group consisting of -alkyl, -aryl and -heteroaryl; and R7 is selected from the group consisting of -alkyl, -aryl and -heteroaryl. |
