Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps

摘要

Method for enantioseparation of a chiral system with compound formation comprising a pair of enantiomers. The method comprises the steps of: placing the chiral system to be processed, which is optically enriched by a target enantiomer, in the 3-phase region of the ternary phase diagram of chiral compound forming systems to achieve the establishment of the solid/liquid phase equilibria; phase-separating the liquid and solid phase formed by the placing step; shifting the eutectic composition of the remaining liquid towards a lower eutectic composition (xE) until the overall composition is located in the 2-phase region of the ternary phase diagram of chiral compound forming systems; and performing crystallization in the 2-phase region of the ternary phase diagram for obtaining the target enantiomer in the solid phase. In some cases the shifting step can be skipped.

主权项

1. A method for enantioseparation of a chiral system with racemic compound formation comprising a pair of enantiomers, the method comprising the steps of:
placing the chiral system to be processed, which is optically enriched by a target enantiomer, in the 3-phase region of the ternary phase diagram of chiral compound forming systems to achieve the establishment of the solid/liquid phase equilibria; phase-separating the liquid and solid phase formed by the placing step; shifting the eutectic composition of the remaining liquid towards a lower eutectic composition (xE) closer to the racemic composition to achieve a new ternary phase diagram; placing the overall composition in the outer 2-phase region of the new ternary phase diagram; and performing crystallisation in the outer 2-phase region of this new ternary phase diagram for obtaining the target enantiomer in the solid phase.