| 主权项 |
1. An oligomeric compound comprising at least one tricyclic nucleoside having formula II:wherein independently for each of said tricyclic nucleosides having formula II:
Bx is a heterocyclic base moiety; one of T1 and T2 is an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligomeric compound and the other of T1 and T2 is hydroxyl, a protected hydroxyl, a phosphate moiety, a 5′ or 3′-terminal group or an internucleoside linking group attaching said tricyclic nucleoside of formula II to said oligomeric compound; q1, q2, q3 and q4 are each, independently, H, halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, substituted C1-C6 alkyl, substituted C2-C6 alkenyl or substituted C2-C6 alkynyl; z1 and z2 are each, independently, halogen, C1-C6 alkyl, O—C1-C6 alkyl, O—C2-C6 alkenyl, O—C2-C6 alkynyl, substituted C1-C6 alkyl, substituted O—C1-C6 alkyl, substituted O—C2-C6 alkenyl or substituted O—C2-C6 alkynyl; wherein each substituted group is, independently, mono or poly substituted with optionally protected substituent groups independently selected from halogen, oxo, N3, CN, OE1, N(E1)(E2), O—N(E1)(E2), C(═O)N(E1)(E2), C(═O)—N(E3)-(CH2)r—N(E1)(E2) and CH2—N(H)—C(═NE3)[N(E1)(E2)] wherein each E1, E2 and E3 is, independently, H, C1-C6 alkyl or a protecting group and r is from 2 to about 6; and wherein said oligomeric compound comprises from about 8 to about 40 linked monomeric subunits and is complementary to at least a portion of a target RNA; and wherein at least one of q1, q2, q3, q4, z1 and z2 is other than H. |
