| 发明名称 | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof | ||
| 摘要 | The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period. | ||
| 申请公布号 | US8993761(B2) | 申请公布日期 | 2015.03.31 |
| 申请号 | US201313749753 | 申请日期 | 2013.01.25 |
| 申请人 | Otsuka Pharamceutical Co. Ltd. | 发明人 | Bando Takuji;Aoki Satoshi;Kawasaki Junichi;Ishigami Makoto;Taniguchi Youichi;Yabuuchi Tsuyoshi;Fujimoto Kiyoshi;Nishioka Yoshihiro;Kobayashi Noriyuki;Fujimura Tsutomu;Takahashi Masanori;Abe Kaoru;Nakagawa Tomonori;Shinhama Koichi;Utsumi Naoto;Tominaga Michiaki;Ooi Yoshihiro;Yamada Shohei;Tomikawa Kenji |
| 分类号 | C07D403/12;C07D215/227 | 主分类号 | C07D403/12 |
| 代理机构 | Finnegan, Henderson, Farabow, Garrett & Dunner LLP | 代理人 | Finnegan, Henderson, Farabow, Garrett & Dunner LLP |
| 主权项 | 1. Hydrate A of aripiprazole having an endothermic curve comprising a first endothermic peak at about 71° C. and a second endothermic peak around 60° C. to 120° C. in a thermogravimetric or differential thermal analysis (heating rate 5° C./min). | ||
| 地址 | Tokyo JP | ||