| 发明名称 |
Methods of increasing bone mass in a subject comprising inhibiting DKK1 |
| 摘要 |
The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which Wnt signaling antagonist inhibits bone differentiation. Also disclosed herein are methods to control bone loss, treat bone disease and prevent tumor growth in bones of individual. |
| 申请公布号 |
US8992909(B2) |
申请公布日期 |
2015.03.31 |
| 申请号 |
US201213402698 |
申请日期 |
2012.02.22 |
| 申请人 |
Board of Trustees of the University of Arkansas |
发明人 |
Shaughnessy, Jr. John D;Barlogie Bart;Qiang Ya-Wei |
| 分类号 |
A61K39/395;A61K39/00;C07K16/18;C07K16/30;C12Q1/68;G01N33/68 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
Adler Benjamin Aaron |
| 主权项 |
1. A method of increasing osteoblast activity in a subject exhibiting increased DKK1 activity or expression, comprising the step of:
administering to the subject an agent that is a DKK1 neutralizing antibody that binds a DKK1 protein consisting of the sequence encoded by the DKK1 gene consisting of the sequence shown in SEQ ID No: 47, wherein the agent inhibits the activity of the DKK1 protein. |
| 地址 |
Little Rock AR US |
