BIS-PLATINUM COMPLEXES WITH ANTITUMOR ACTIVITY

摘要

A compound of general formula (I): (see formula I) in which: R is (C3-C7)alkyl; n and m are each independently an integer of five or six; p is one or two; A is -W-(CH2)r-W-, wherein r is an integer from 2 to 4, W is a -NR1- or -N(R2)2+ 1/pQ-p group, in which R1 is hydrogen or tert-butoxycarbonyl, and R2 is hydrogen; Q-p is an anion selected from the group consisting of chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, and perchlorate, R3COO- wherein R3 has the same meanings as R, independently from one another, and R4-O-SO3- wherein R4 is (C2-C14)alkyl with the proviso that, when Q-p is chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, or perchlorate, R is not (C3-C4)alkyl. The compounds of the present invention are useful in the preparation of medicaments for the treatment of tumours.