4-(azacycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and in cosmetics

摘要

4-(Azacycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below:;
Also described, are compositions including the same, processes for preparation thereof and uses thereof in pharmaceutical or cosmetic compositions to treat pigmentary disorders.

主权项

1. A pharmaceutical or cosmetic composition comprising a compound of formula (I) below: in which: R1 represents:
a C1-C5 alkyl radical,a C3-C5 cycloalkyl radical,an aryl radical,a substituted aryl radical,an aralkyl radical,a C1-C5 alkoxy radical,an amino radical corresponding to structure (a): in which R2 represents:a hydrogen,a C1-C5 alkyl radical,a C3-C6 cycloalkyl radical,an aryl radical,
a substituted aryl radical,a pyridyl radical,an aralkyl radical,a radical corresponding to structure (b): in which p can have the value 1 or 2,a radical corresponding to structure (c): in which R4 represents:
a carboxymethyl —COOCH3 or carboxyethyl —COOEt radical,a C1-C3 alkyl radical,a hydrogen,and R5 represents:
a substituted or unsubstituted aryl radical,a C3-C6 cycloalkyl radical,a pyridyl,and R3 represents:
a hydrogen,a C1-C5 alkyl radical; or R1 may also represent a radical corresponding to formula (d): in which R6 represents:a hydrogen,a C1-C5 alkyl radical,a C3-C6 cycloalkyl radical,an aryl radical,a substituted aryl radical,a pyridyl radical,an aralkyl radical, R7 represents:
a hydrogen,a C1-C5 alkyl radical, and R8 represents:
a hydrogen,a hydroxyl,an amino radical,a C1-C5 alkoxy radical: Y represents a hydrogen or a fluorine, and m and n can have the value 0, 1 or 2, or a salt of a compound of formula (I), or an enantiomer form thereof; and a pharmaceutically acceptable or cosmetically acceptable carrier.