| 主权项 |
1. A method of increasing the testosterone blood level of an adult male subject in need thereof comprising applying to at least one axilla of the subject, without occlusion by a patch device, a transdermal drug delivery composition comprising:
(a) a pharmaceutically effective amount of testosterone; (b) one or more lower alkyl alcohols, wherein the combined amount of lower alkyl alcohols is more than 60% v/v of the composition; (c) one or more penetration enhancers selected from the group consisting of oleic acid, fatty acid esters, fatty alcohols, glycols, glycol esters, 1,3-dioxolanes, 1,3-dioxanes, macrocyclic ketones containing at least 12 carbon atoms, oxazolidinones, alkyl-2-(N,N-disubstituted amino)-alkanoate esters, (N,N-disubstituted amino)-alkanol alkanoates, sunscreen esters and mixtures thereof; and (d) a viscosity modulating agent for increasing the viscosity of the composition. |
