发明名称 |
METHOD AND COMPOSITIONS FOR CELLULAR IMMUNOTHERAPY |
摘要 |
<p>The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor. In embodiments the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a ligand binding domain, a polynucleotide comprising a customized spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain. It has been surprisingly found that the length of the spacer region can affects the ability of chimeric receptor modified T cells to recognize target cells in vitro and affects in vivo efficacy of the chimeric receptor modified T cells. Pharmaceutical formulations produced by the method, and methods of using the same, are also described.</p> |
申请公布号 |
SG11201501259Q(A) |
申请公布日期 |
2015.03.30 |
申请号 |
SG11201501259Q |
申请日期 |
2013.08.20 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER;SEATTLE CHILDREN'S HOSPITAL, DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE |
发明人 |
JENSEN, MICHAEL;RIDDELL, STANLEY, R.;HUDECEK, MICHAEL |
分类号 |
A61K39/395;C07K14/705;C12N5/10;C12N15/62 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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