Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases

摘要

A therapeutic composition, comprising an isolated amino acyl-tRNA synthetase (AARS) polypeptide of up to about 300 amino acids in length that comprises SEQ ID NO: 12 or 34 or an amino acid sequence that is at least 90% identical to SEQ ID NO: 12 or 34, wherein the AARS polypeptide has an extracellular signalling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin / mg protein.