发明名称 |
Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies |
摘要 |
<p>Discloses isolated bivalent antibodies or a bivalent fragment thereof to a low density lipoprotein-related protein 6 (LRP6) that potentiates a Wnt signal by clustering one or more LRP6 receptors in the presence of an unblocked LRP6 binding protein, and an isolated monovalent antibody or monovalent binding fragment thereof to a LRP6 that avoids potentiating a Wnt signal by clustering one or more LRP6 receptors in the presence of an unblocked LRP6 binding protein. Further discloses specific sequence structures of such antibodies and use in the treatment of cancer.</p> |
申请公布号 |
NZ603829(A) |
申请公布日期 |
2015.03.27 |
申请号 |
NZ20110603829 |
申请日期 |
2011.05.05 |
申请人 |
NOVARTIS AG |
发明人 |
HARTLEPP FELIX;ETTENBERG SETH;CONG FENG;KLAGGE INGO |
分类号 |
C07K16/28;A61K39/395;A61P35/00;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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