| 发明名称 |
Peptide-based in vivo sirna delivery system |
| 摘要 |
<p>Disclosed is a conjugate delivery system composition for delivering an RNA interference polynucleotide to a liver cell in vivo comprising: RNAi-A + Melittin-(L-Gal)x wherein, Melittin is a melittin peptide; L is physiologically labile linkage; Gal is an Asialoglycoproteln Receptor (ASGPr) ligand; x is an integer having a value greater than 80% of primary amines of Melittin; RNAi is an RNA interference polynucleotide; and A is either a hydrophobic group having at least 20 carbon atoms or a galactose cluster.</p> |
| 申请公布号 |
NZ611662(A) |
申请公布日期 |
2015.03.27 |
| 申请号 |
NZ20110611662 |
申请日期 |
2011.12.16 |
| 申请人 |
ARROWHEAD RESEARCH CORPORATION |
发明人 |
ROZEMA DAVID B.;WOLFF JON A.;BLOKHIN ANDREI V.;BENSON JONATHAN D.;LEWIS DAVID L.;KITAS ERIC A;HADWIGER PHILIPP;HOFFMANN TORSTEN;JAHN-HOFMANN KERSTIN;MUELLER HANS MARTIN;OTT GUENTHER;MOHR PETER;ROEHL INGO;WAKEFIELD DARREN H.;CARLSON JEFFREY C. |
| 分类号 |
A61K31/713;A61P1/16;A61P3/00;A61P3/06;A61P3/10;A61P31/20;A61P35/00 |
主分类号 |
A61K31/713 |
| 代理机构 |
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