发明名称 |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
摘要 |
Discloses a therapeutic composition, comprising an isolated aminoacyl-tRNA synthetase (AARS) polypeptide of up to 300 amino acids in length that comprises SEQ ID NO: 16 or 14 or an amino acid sequence that is at least 90% identical to SEQ ID NO: 16 or 14, wherein the AARS polypeptide has an extracellular signalling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin / mg protein. |
申请公布号 |
NZ603811(A) |
申请公布日期 |
2015.03.27 |
申请号 |
NZ20110603811 |
申请日期 |
2011.07.11 |
申请人 |
ATYR PHARMA INC.;PANGU BIOPHARMA LIMITED |
发明人 |
WATKINS JEFFRY D.;MENDLEIN JOHN D.;HONG FEI;GREENE LESLIE ANN;CHIANG KYLE P.;VASSEROT ALAIN P.;QUINN CHERYL L.;LO WING-SZE |
分类号 |
A61K38/16;A61K38/08;A61K38/10;A61K39/395;A61P3/00;A61P3/10;A61P35/00 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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