Methods and compositions for diagnosis and prognosis of renal injury and renal failure

摘要

A method for evaluating renal status in a subject ex vivo, comprises performing one or more assays configured to detect one or more biomarkers present in a body fluid sample obtained previously from the subject where at least one biomarker is Apolipoprotein E; determining on the body fluid sample one or more assay result(s); and correlating the assay result(s) to the renal status of the subject/. The correlating comprises comparing a measured concentration of Apolipoprotein E to a threshold concentration of Apolipotein E and assigning a likelihood of an event occurring or assigning a likelihood of an event occurring when the measured concentration varies from the threshold.