| 摘要 |
FIELD: chemistry.SUBSTANCE: invention refers to methods for preparing functionally substituted condensed heterocyclic molecules, more specifically 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricar- bonitriles, wherein R=R=Me, R=Et (1); R=R=Me, R=Pr (2); R=R=Me, R=i-Pr (3); R=R=Me, R=Bu (4); R=R=Me, R=Ph (5); R=R=Me, R=4-Me-CH(6); R=R=Me, R=3-F-CH(7); R=R=Me, R=4-MeO-CH(8); R=R=Me, R=4-NO-CH(9); R=R-Me, R=2-Fu (10); R=R=Me, R=2-Thi (11); R=Et, R=Me, R=Ph (12); R=Et, R=Me, R=4-MeO-CH(13); R=Et, R=Me, R=4-NO-CH(14); R=Et, R=Me, R=2-Pyr (15); R=Et, R=Me, R=2-Fu (16); R=Me, R=Pr, R=Pr (17); R=Me, R=Pr, R=i-Pr (18); R=Me, R=Pr, R=Ph (19); R=Me, R=Ph, R=Et (20); R=Me, R=Ph, R=i-Pr (21); R=Me, R=Ph, R=Bu (22); R=Me, R=Ph, R=Ph (23); R=Me, R=Ph, R=3-F-CH(24); R=Me, R=Ph, R=4-NO-CH(25); R=Me, R=Ph, R=2-Fu (26); R+R=(CH), R=Pr (27); R+R=(CH), R=i-Pr (28); R+R=(CH), R=Ph (29); R+R=(CH), R=3-F-CH(30); R+R=(CH), R=4-MeO-CH(31); R+R=(CH), R=4-NO-CH(32); R+R=(CH), R=2-Pyr (33): R+R=(CH), R=2-Fu (34); R+R=(CH), R=2-Thi (35); R+R=(CH).S R-Ph (36); R+R=(CH), R=3-F-CH(37); R+R=(CH); R=2-Pyr (38), which can be used as biologically active compounds. The method consists in the fact that respective 4-oxoalkane-1,1,2,2-tetracarbonitrile in aqueous acetic acid in the concentration of 50-85%; thereafter a reaction mass is added with respective 1,3,5-trisubstituted 2,4-diazapenta-1,4-diene in molar ratio 2:1; the reaction mass is agitated for 20-30 minute unit an end product is prepared.EFFECT: fastening and simplifying the process.38 ex |
