Anti-Activin A Antibodies and Uses Thereof

摘要

The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and an isolated antigen binding protein that specifically binds a cysteine knot domain in Activin A, wherein the antigen binding protein binds a region selected from the group consisting of amino acids 11-33 of SEQ ID NO:1, amino acids 81-111 of SEQ ID NO:1, and amino acids 11-33 and 81-111 of SEQ ID NO:1.