发明名称 STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS
摘要 The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
申请公布号 US2015086544(A1) 申请公布日期 2015.03.26
申请号 US201414554804 申请日期 2014.11.26
申请人 MEDIMMUNE, LLC 发明人 Oliver Cynthia N.;Shane Erica;Isaacs Benjamin S.;Allan Christian B.;Chang Stephen T.
分类号 C07K16/10 主分类号 C07K16/10
代理机构 代理人
主权项
地址 Gaithersburg MD US