POLYMERIC MICROEMULSIONS

摘要

The invention provides novel self-emulsifying diblock copolymers and novel self-emulsifying compositions comprising an active ingredient and a diblock copolymer characterized in that the diblock copolymer is liquid at a temperature below 50° C. and the composition is non-aqueous and liquid at a temperature below 50° C.

主权项

1. A self-microemulsifying composition comprising an active ingredient and a diblock copolymer of formula A-B
wherein polymer block A represents a linear pharmaceutically acceptable hydrophilic polymer with a molecular weight <1,000, and polymer block B represents a polymer comprising at least two different monomers selected from glycolic acid, propiolactone, γ-butyrolactone, δ-valerolactone, γ-valerolactone, ε-caprolactone, trimethylene carbonate, p-dioxanone, tetramethylene carbonate, ε-lactone, 1,5-dioxepan-2-one wherein the diblock copolymer is liquid at a temperature below 50° C., wherein the composition does not comprise separate oil and surfactant components, and wherein the composition provides active ingredient-loaded micellar solutions.