METHODS OF USING STRUCTURALLY INTERACTING RNA

摘要

Disclosed are RNA constructs which function to bind and/or inhibit a non-coding RNA (e.g., a miRNA). Such RNA constructs include an optionally weakened stem-loop structure stabilized by binding to a non-coding RNA. The non-coding RNA preferentially binds to the RNA construct as compared to a natural target (e.g., a mRNA). In certain embodiments, the RNA construct inhibits the function of the non-coding RNA. Such RNA constructs also have three-way junction joining regions 3' and 5' of the stem-loop structure.