发明名称 |
USE OF EGFR PATHWAY INHIBITORS TO INCREASE IMMUNE RESPONSES TO ANTIGENS |
摘要 |
This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In certain embodiments, the EGFR pathway inhibitor is administered under conditions such that memory cells to the antigen are formed in a subject. In certain embodiments, the composition is a vaccine. In certain embodiments, the EGFR pathway inhibitor and vaccine are administered to the skin epidermis or dermis. |
申请公布号 |
WO2015042567(A1) |
申请公布日期 |
2015.03.26 |
申请号 |
WO2014US56930 |
申请日期 |
2014.09.23 |
申请人 |
EMORY UNIVERSITY |
发明人 |
POLLACK, BRIAN P.;COMPANS, RICHARD W.;PULIT-PENALOZA, JOANNA A.;SKOUNTZOU, IOANNA |
分类号 |
A61K31/47;A61K31/505;A61K31/517;A61P37/00 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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