METHODS AND COMPOSITIONS FOR REDUCING THE PROLIFERATION OF GRAM POSITIVE BACTERIA

摘要

Provided herein are methods for inducing cell death in a gram positive bacterium and methods for reducing the proliferation of a gram positive bacterium that include contacting a gram positive bacterium with a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are methods of treating a subject having a gram positive bacterial infection that include administering to a subject having a gram positive bacterial infection a dye (e.g., an azo dye) and a TarO inhibitor. Also provided are compositions containing a dye (e.g., an azo dye) and a TarO inhibitor, and kits containing at least one of these compositions.

主权项

1. A method for inducing cell death in a gram positive bacterium, the method comprising contacting a gram positive bacterium with an azo dye and a TarO inhibitor in amounts sufficient to induce cell death in the gram positive bacterium.