Inhibition of Opioid Antinociceptive Tolerance and Withdrawal in Nociceptive Pain Therapy

摘要

The invention provides methods and compositions for inhibiting opioid tolerance by administering an A3AR agonist to a subject receiving opiate therapy for nociceptive pain. Also provided are methods of treating opiate withdrawal using an A3AR agonist.

主权项

1. A method of reducing opioid antinociceptive tolerance in a subject receiving opiate therapy for acute/severe and chronic neuropathic (malignant and non malignant) pain comprising administering to said subject an amount of an A3AR agonist sufficient to reduce opioid antinociceptive tolerance.