| 发明名称 |
MICRORNA COMPOSITIONS AND METHODS |
| 摘要 |
Provided herein are compositions comprising oligomeric compounds. In certain embodiments, the oligomeric compounds are useful as miRNA mimics. The oligomeric compounds may mimic the activity of miR-34. Also provided herein are methods for the treatment of cancer. |
| 申请公布号 |
US2015087607(A1) |
申请公布日期 |
2015.03.26 |
| 申请号 |
US201414467269 |
申请日期 |
2014.08.25 |
| 申请人 |
REGULUS THERAPEUTICS INC. ;ALNYLAM PHARMACEUTICALS |
发明人 |
Marcusson Eric G.;Bhat Balkrishen;Linsley Peter;Akinc Akin |
| 分类号 |
C12N15/113;A61K45/06;A61K31/713 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer comprising administering to a subject having cancer a composition comprising an oligomeric compound comprising an oligonucleotide consisting of 7 to 30 linked nucleosides, wherein the nucleobase sequence of the oligonucleotide has at least 80% seed region identity with the nucleobase sequence of miR-34. |
| 地址 |
San Diego CA US |
