METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF TISSUE OR ORGAN FIBROSIS IN A REPARATIVE OR REACTIVE PROCESS

摘要

The invention relates to methods of diagnosis or prognosis of a tissue or organ fibrosis (e.g., skin fibrosis, hypertrophic scar or a keloid) in a reparative or reactive process comprising the step of determining the levels of expression of genes encoding different molecular markers in a sample of a tissue or organ from a mammalian, wherein different genes markers are studied.

主权项

1. A method of diagnosis or prognosis of a tissue or organ susceptible of developing a fibrosis, such as a lung or skin fibrosis, comprising the step of determining the levels of expression of genes encoding different molecular markers in a sample of a tissue or organ from a mammalian, wherein said genes are defined as follows:
at least one of the following genes show increased expression when compared with the expression in normal fibroblasts of said mammalian: EDIL3, EFHD1, FOXS1, HAPLN1, INHBA4, KRT16, MICAL2, PI16, POU2F2 and UCN2, or at least one of the following genes show decreased expression when compared with the expression in normal fibroblasts of said mammalian: APOD, CFB, CXCL1, KIT, MED12L, NR4A3, PTX3, RCAN2, STC1 and TFPI2.