The invention relates to compositions and methods that utilize polymeric nanoparticles to deliver a therapeutic compound to ocular cells or ocular tissue. Provided is a drug-loaded micelle comprising self-assembled amphiphilic biopolymers, such as hydrophobically modified nucleic acids or polypeptides, for use as ophthalmic drug delivery system. Also provided are ophthalmic compositions and methods for preventing or treating an ophthalmic disease.
申请公布号
WO2015041520(A1)
申请公布日期
2015.03.26
申请号
WO2014NL50634
申请日期
2014.09.17
申请人
RIJKSUNIVERSITEIT GRONINGEN;EBERHARD- KARLS- UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT
发明人
HERRMANN, ANDREAS;DE VRIES, JAN WILLEM;SPITZER, MARTIN STEPHAN;SCHNICHELS, SVEN OLIVER