| 发明名称 |
DIASPIRIN CROSSLINKED PEGYLATED HEMOGLOBIN |
| 摘要 |
PEGylated diaspirin-crosslinked hemoglobin conjugates having high oxygen affinity are described which have enhanced nitrite reductase activity to deliver oxygen, carbon monoxide, nitric oxide or mixtures thereof to tissues to treat various diseases and conditions. |
| 申请公布号 |
US2015087590(A1) |
申请公布日期 |
2015.03.26 |
| 申请号 |
US201314388956 |
申请日期 |
2013.03.15 |
| 申请人 |
SANGART, INC. |
发明人 |
Vandegriff Kim D.;Malavalli Ashok;Olsen Scott D. |
| 分类号 |
A61K38/42;C07K1/10;A61K47/48 |
主分类号 |
A61K38/42 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A β,β-intramolecularly-crosslinked polyoxyalkylene oxide hemoglobin conjugate having a P50 ranging from about 2 to 5 mmHg as measured at 37° C. and pH 7.4, wherein the hemoglobin conjugate when fully deoxygenated at 25° C. exhibits a maximal nitrite reductase activity that is at least 10-fold greater than that of deoxygenated stroma-free hemoglobin when measured under the same conditions. |
| 地址 |
San Diego CA US |
