Compliant Surgical Adhesive

摘要

Surgical adhesives that include a blend of two different thermoreversible gelling polymers and a crosslinking agent are described. The first thermoreversible gelling polymer is partially or fully acrylated and the second thermoreversible gelling polymer includes dual functionality including acrylate functionality and amine-reactive functionality. The adhesives can provide gelling and covalent crosslinking within the polymers of the adhesive as well as crosslinking with surrounding tissue.

主权项

1. A gel-forming composition comprising:
a first thermoreversible gelling block copolymer that includes a hydrophilic block and a hydrophobic block, the first thermoreversible gelling copolymer including acrylate functionality in at least a portion of the termini of the copolymer; a second thermoreversible gelling block copolymer that differs from the first thermoreversible gelling block copolymer and includes a hydrophilic block and a hydrophobic block, the second thermoreversible gelling copolymer including acrylate functionality on a portion of the termini of the copolymer and including amine-reactive functionality on a portion of the termini, the hydrophilic block of the second thermoreversible gelling block copolymer being the same or different as the hydrophilic block of the first thermoreversible gelling block copolymer and the hydrophobic block of the second thermo reversible gelling block copolymer being the same or different as the hydrophobic block of the first thermoreversible gelling block copolymer; and a polyfunctional thiol crosslinker; the composition comprising the first thermoreversible gelling block copolymer and the second thermoreversible gelling block copolymer in a blend at a ratio of from about 10:90 to about 90:10 by weight, respectively.