<p>TERT promoter mutations occur in both papillary and flat lesion bladder cancers, are the most frequent genetic alterations identified to date in noninvasive precursor lesions of the bladder, are detectable in urine, and appear to be strongly associated with bladder cancer recurrence. The TERT promoter mutations are useful urinary biomarker for both the early detection and monitoring of bladder neoplasia.</p>
申请公布号
WO2015041788(A1)
申请公布日期
2015.03.26
申请号
WO2014US51808
申请日期
2014.08.20
申请人
THE JOHNS HOPKINS UNIVERSITY
发明人
VOGELSTEIN, BERT;KINZLER, KENNETH W.;DIAZ, LUIS;PAPADOPOULOS, NICKOLAS;NETTO, GEORGE J.;HRUBAN, RALPH;KINDE, ISAAC A.