| 发明名称 |
METHOD OF CONTROLLING INITIAL DRUG RELEASE OF siRNA FROM SUSTAINED-RELEASE IMPLANTS |
| 摘要 |
The present invention provides an intraocular implant comprising siRNA combined with a excipient effective to retard the initial release of the siRNA from an implant, wherein said siRNA and excipient is associated with a biocompatible polymer (e.g., a polymeric matrix), configured to release said siRNA into the eye of a patient at therapeutic levels for a time sufficient to treat an ocular condition or disease. |
| 申请公布号 |
US2015087696(A1) |
申请公布日期 |
2015.03.26 |
| 申请号 |
US201414558229 |
申请日期 |
2014.12.02 |
| 申请人 |
Allergan, Inc. |
发明人 |
Rivers Hongwen M.;Spada Lon T.;Luu Michelle |
| 分类号 |
A61K47/34;A61K9/00;C12N15/113 |
主分类号 |
A61K47/34 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A biodegradable intraocular implant comprising
an excipient; a small interfering RNA (siRNA); and a poly (D,L lactide-co-glycolide) polymer with a monomer ratio of 75:25 and an inherent viscosity of 0.2 dL/g. |
| 地址 |
Irvine CA US |
