发明名称 |
FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX |
摘要 |
<p>Fused pyrimidine compounds having a saturated, unsaturated or aromatic A ring fused to a pyrimidine ring and having a complex substituents at the 2 position and a substituted amine at the 4 position of the pyrimidine ring as well as optional aliphatic, functional and/or aromatic components substituted at other positions of the pyrimidine ring and A ring are disclosed. These compounds are inhibitors of the AAA proteasome complex containing p97 and are effective medicinal agents for treatment of diseases associated with p97 bioactivity such as cancer.</p> |
申请公布号 |
KR20150032588(A) |
申请公布日期 |
2015.03.26 |
申请号 |
KR20157004477 |
申请日期 |
2013.07.19 |
申请人 |
CLEAVE BIOSCIENCES, INC. (CLEAVE) |
发明人 |
ZHOU HAN JIE;PARLATI FRANCESCO;WUSTROW DAVID |
分类号 |
A61K31/517;A61K31/519;C07D403/04;C07D471/04;C07D491/052;C07D513/04 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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